最近の発表論文
- Computational Study for the Aromatic Nucleophilic Substitution of 4-Dimethylamino-3-trifluoroacetylquinoline
with Various Nucleophiles,
N. Ota, S. Nakagawa, Y. Kamitori, E. Okada,
Heterocycles, 2021, 103, 918. - SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION OF 4-DIMETHYLAMINO-2-METHOXY-3-
(TRIFLUOROACETYL)QUINOLINE WITH ALCOHOLS － DFT CALCULATION STUDY,
N. Ota, Y. Harada, Y. Kamitori, E. Okada,
Heterocycles, 2020, 101, 692. - SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION OF 4-(DIMETHYLAMINO)-2-METHOXY-
3-(TRIFLUOROACETYL)QUINOLINE WITH THIOLS - DFT CALCULATION STUDY,
N. Ota, Y. Harada, Y. Kamitori, E. Okada,
Heterocycles, 99, No. 1, 694 (2019). - COMPUTATIONAL STUDY FOR THE SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION
ON 4-DIMETHYLAMINO- 2-METHOXY-3-TRIFLUOROACETYLQUINOLINE,
N. Ota, S. Sasakawa, Y. Kamitori, E. Okada,
Heterocycles, 97, No. 1, 451 (2018). - Computational Study for the Aromatic Nucleophilic Substitution Reaction on
1-Dimethylamino-2,4-bis(trifluoroacetyl)naphthalene with Amines,
N. Ota, T. Nakada, T. Shintani, Y. Kamitori, E. Okada,
Int. J. Org. Chem. 8, 273 (2018). - Efficient Synthesis of Fluorine-Containing Dibenzo[b,h][1,6]naphthyridines and Thiochromeno[3,2-c]quinolines Using
Highly Chemoselective Nucleophilic Substitution Reaction of 4-Dimethylamino-2-methoxy-3-trifluoroacetylquinoline,
E. Okada, M. Hatakenaka, Y. Takezawa, Keisuke Iwakuni,
Heterocycles, 95, No.1, 322 (2017). - Facile and Convenient Syntheses of Fluorine-Containing Pyrimido[5,4-c]quinolines and Benzo[h][1,6]naphthyridines by
Condensation Reaction of 2-Methoxy-3-trifluoroacetyl-4-quinolylamine with Aldehydes and Ketones,
M. Hatakenaka, E. Okada,
Heterocycles, 94, No.1, 102 (2017). - Unexpected Highly Chemoselective Nucleophilic Substitution Reaction of
4-Dimethylamino-2-methoxy-3-trifluoroacetylquinoline with Various Nucleophiles,
E. Okada, M. Hatakenaka, Y. Takezawa, Keisuke Iwakuni,
Heterocycles, 93, No.2, 474 (2016). - COMPUTATIONAL STUDY FOR 1,5-SIGMATROPIC HYDROGEN SHIFT ON
TRIFLUOROMETHYLAZADIENE DERIVATIVES - THE KEY STEP IN THE SYNTHESIS OF
FLUORINE-CONTAINING OXAZINES -,
N. Ota, Y. Kamitori, T. Okuda, E. Okada,
Heterocycles, 93, No.1, 243 (2016). - Facile Syntheses of Fluorine-Containing 4-Methoxypyrazolo[4,3-c]quinolines and 6-Methoxy-1,4-diazepino-
[6,5-c]quinolines,
M. Hatakenaka, S. Adachi, E. Okada,
Heterocycles, 92, 936 (2016). - FACILE AND CONVENIENT SYNTHESES FOR FLUORINE-CONTAINING
PYRAZOLO[4,3-c]QUINOLINES, ISOXAZOLOQUINOLINES, AND 1,4-DIAZEPINO[6,5-c]QUINOLINES
E. Okada, M. Hatakenaka, T. Sakaemura,
Heterocycles, 90, No.2, 1072 (2015). - EFFICIENT SYNTHESES OF FLUORINE-CONTAINING PYRIMIDO[5,4-c]QUINOLINES AND BENZO-
[h][1,6]NAPHTHYRIDINES BY CONDENSATION REACTIONS OF 3-TRIFLUORO-
ACETYLQUINOLIN-4-AMINE WITH ALDEHYDES AND KETONES
E. Okada, M. Hatakenaka, S. Nakano, T. Sakaemura, T. Mori, T. Terauchi,
Heterocycles, 89, No.10, 2303 (2014). - A FACILE AND CONVENIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING
DIBENZO[b,h][1,6]NAPHTHYRIDINES,
THIOCHROMENO[3,2-c]QUINOLINES, AND CHROMENO[3,2-c]QUINOLINES
E. Okada, M. Hatakenaka, M. Kuratani, T. Mori, T. Ashida,
Heterocycles, 88, No.1, 799 (2014). - A VERSATILE METHOD FOR THE SYNTHESIS OF FLUORINE-CONTAINING CHLOROQUINE ANALOGUES STARTING FROM 7-CHLORO-4-(N,N-DIMETHYLAMINO)QUINOLINE USING NUCLEOPHILIC N-N, N-S, AND N-O EXCHANGE REACTIONS
N. Ota, M. Hatakenaka, T. Ashida, E. Okada,
Heterocycles, 87, No.12, 2641 (2013). - Incorporation of a 3.(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam Motif in the Side Chain of
4.Aminoquinolines. Syntheses and AntimalarialActivities,
D. Cornut, H. Lemoine, O. Kanishchev, E. Okada, F. Albrieux, A. H. Beavogui, A.-L. Bienvenu,
S. Picot, J.-P. Bouillon, M. Me.debielle,
J. Med. Chem., 56, 73 (2013). - SIMPLE SYNTHESES OF 3-TRIFLUOROACETYL-4-QUINOLYLAMINES, SULFIDES, AND ETHERS
STARTING FROM N,N-DIMETHYL-4-QUINOLYLAMINE
E. Okada, M. Hatakenaka, T. Sakaemura, N. Shimomura, T. Ashida,
Heterocycles, 86, No.2, 1177 (2012). - COMPUTATIONAL STUDY ON ACID CATALYZED RING-OPENING REACTION OF
2,4-DIETHOXY-6-TRIFLUOROMETHYL- 3,4-DIHYDRO-2H-PYRAN WITH THIOLS
N. Ota, Y. Kamitori, M. Hatakenaka, E. Okada,
Heterocycles, 86, No.1, 705 (2012). - Computational Study on the Acid Catalyzed Reactions of Fluorine-Containing
2,4-Dialkoxy-3,4-dihydro-2H-pyrans with Aromatic Compounds,
N. Ota, Y. Kamitori, R. Shirai, M. Hatakenaka, E. Okada,
Appl. Sci., 2, 129 (2012). - A FACILE AND CONVENIENT METHOD FOR THE SYNTHESIS OF 6,8-BIS(TRIFLUOROACETYL)QUINOLINE-5-AMINES,
Dai Shibata, Maurice Medebielle, Mizuki Hatakenaka, and Etsuji Okada,
Heterocycles, 84, No. 2, 1277 (2012). - A MOLECULAR ORBITAL CALCULATION STUDY ON RING-OPENING REACTIONS OF FLUORINE-CONTAINING
3,4-DIHYDRO-2H-PYRANS WITH AMINES AND THIOLS,,
Norio Ota, Yasuhiro Kamitori, Yusuke Tamai, Guo Feng, Mizuki Hatakenaka, and Etsuji Okada,
Heterocycles, 83, No. 11, 2509 (2011). - Facile and Convenient Synthesis of Fluorine-Containing Pyrido[2,3-h]quinolines and 1,7-Phenanthrolines by
Condensation Reaction of 6,8-Bis(trifluoroacetyl)quinoline-5-amine with Carbonyl Compounds,
Mamoru Hinoshita, Dai Shibata, Mizuki Hatakenaka, and Etsuji Okada,
Synthesis, 2754 (2011). - A MOLECULAR ORBITAL CALCULATION STUDY ON THE INTERESTING REACTIVITY OF
FLUORINE-CONTAINING 3,4-DIHYDRO-2H-PYRANS WITH AROMATIC COMPOUNDS IN THE PRESENCE OF
TRIFLUOROACETIC ACID,
Norio Ota, Yasuhiro Kamitori, Eisuke Nishiguchi, Makoto Ishii, and Etsuji Okada,
Heterocycles, 82, No. 2, 1337 (2011). - A FACILE SYNTHESIS OF FLUORINE-CONTAINING 1,7-PHENANTHROLINES BY THE CYCLIZATION OF
N-PROPARGYL-6,8-BIS(TRIFLUOROACETYL)QUINOLIN-5-AMINE WITH VARIOUS ACTIVE METHYLENE
COMPOUNDS,
Dai Shibata, Ayaka Sakai, Mizuki Hatakenaka, Shohei Saikawa, Yasuhiro Kamitori, Maurice Medebielle, and
Etsuji Okada,
Heterocycles, 82, No. 1, 803 (2010). - A CONCISE SYNTHESIS OF FLUORINE-CONTAINING BENZO[h]QUINOLINES AND BENZO[h]QUINOLONES BY SELECTIVE PYRIDINE
AND PYRIDINONE RINGS FORMATION REACTIONS OF N-PROPARGYL-2,4-BIS(TRIFLUOROACETYL)-1-NAPHTHYLAMINE
WITH VARIOUS ACTIVE METHYLENE COMPOUNDS,
Etsuji Okada, Dai Shibata, Norikado Tsukushi, Masato Dohura, Norio Ota, Satoru Adachi, and Maurice Medebielle,
Heterocycles, 81, 357 (2010). - A FACILE SYNTHESIS OF 4-ARYL-1,1,1-TRIFLUOROBUT- 3-EN-2-ONES VIA 4-ARYL SUBSTITUTED CF3 - CONTAINING DIHYDROPYRAN DERIVATIVES: A VERSATILE METHOD FOR THE INTRODUCTION OF FLUORINE-CONTAINING C4- AND C6- UNIT TO AROMATIC COMPOUNDS,
Norio Ota, Etsuji Okada, Dai Shibata, Satoru Adachi, and Shohei Saikawa,
Heterocycles, 80, 515 (2010). - HETERO DIELS-ALDER REACTION OF b-TRIFLUOROACETYLATED VINYL ETHERS WITH VINYL ETHERS TO ACCESS
FLUORINE-CONTAINING DIHYDROPYRAN DERIVATIVES: A MOLECULAR ORBITAL CALCULATION STUDY,
N. Ota, Y. Kamitori, D. Shibata, E. Okada,
Heterocycles, 80, 329 (2010). - Fluorine-containing 1,10-phenanthrolines synthesis: an original and efficient approach by the pyridine-ring
formation reaction of N-propargyl-5,7-bis(trifluoroacetyl)-8-quinolylamine with various nucleophiles,
D. Shibata, E. Okada, T. Miyaoku, J. Molette, M. Medebielle,
Tetrahedron, 65, 6189 (2009). - A Facile Synthetic Method for Fluorine-Containing 1,7-Phenanthrolines: Pyridine-Ring Formation Reaction
of N-Propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with Various Nucleophiles,
D. Shibata, E. Okada, M. Hinoshita, M. Medebielle,
Synthesis, 3039 (2009). - Reaction of β-Trifluoroacetylketene Acetals and β-Trifluoroacetylvinyl Ethers with 1,2-Phenylenediamines
Accessing Fluorine-Containing Benzo[b][1,4]diazepine Derivatives: A Molecular Orbital Calculation Study,
N. Ota, Y. Kamitori, N. Terai, T. Sakata, E. Okada,
Heterocycles, 79, 599 (2009). - An Efficient and Selective Synthetic Methods for Fluorine-Containing Benzo[h]quinolines and 1H-Benzo[h]quinolin-2-ones
from N-Propargyl-2,4-bis(trifluoroacetyl)-1-naphthylamine,
E. Okada, D. Shibata, N. Tsukushi, M. Dohura, M. Medebielle,
Heterocycles, 79, 395 (2009). - A Convenient Synthetic Method for Fluorine-Containing 4-Alkoxydihydrobenzo[b][1,4]diazepinols and 3H-Benzo[b][1,4]diazepines by the Reaction of β-Trifluoroacetylketene Acetals with 1,2-Phenylenediamines,
N. Ota, E. Okada, N. Terai, T. Miyamura, D. Shibata, T. Sakata,
Heterocycles, 77, 983 (2009). - Reaction of β,β-Bis(trifluoroacetyl)vinyl Ethers and β-Trifluoroacetylvinyl Ethers with 1,2-Phenylenediamines
Accessing Fluorine-Containing Benzo[b][1,4]diazepine Derivatives - A Study about the Reaction Based on
Molecular Orbital Calculations,
N. Ota, Y. Kamitori, T. Tomoda, N. Terai, E. Okada,
Heterocycles,77, 461 (2009). - Facile Synthesis of Fluorine-Containing 1,10-Phenanthrolines by the Pyridine-Ring Formation Reaction of N-Propargyl-5,7-bis(trifluoroacetyl)-8-quinolylamine with Amines:Isolation of the Intermediates 1,4-Dihydro-1,10-phenanthrolin-4-ols,
D. Shibata, E. Okada, J. Molette, M. Medebielle,
Tetrahedron Lett., 49, 7161 (2008). - Copper Catalyzed 1,3-Dipolar Cycloaddition Reaction of Azides with N-(2-trifluoroacetylaryl)propargylamines.
A Mild Entry to Novel 1,4-Disubstituted-1,2,3-triazole Derivatives,
J.-F. Lamarque, C. Lamarque, S. Lassara, M. Medebielle, J. Molette, E. David, S. Pellet-Rostaing, M. Lemaire,
E. Okada, D. Shibata, G. Pilet,
J. Fluorine Chem., 129, 788 (2008). - A Convenient Synthesis of Fluorine-Containing Dihydrobenzo[b][1,4]diazepinols and Its Application to a Synthesis of
Novel N-Sulfinylanilines,
N. Ota, T. Tomoda, N. Terai, Y. Kamitori, D. Shibata, M. Medebielle, E. Okada,
Heterocycles, 76, 1205 (2008). - One Step Introduction of 4,4-Bis(trifluoroacetyl)-1,3-butadiene System to Aromatic Rings Using Fluorine-Containing 3,4-Dihydro-2H-pyrans. A Facile Synthetic Method for 1,1,1,5,5,5-Hexafluoro-3-
[(E)-3-arylallylidene]pentane-2,4-diones,
N. Ota, E. Okada, A. Sonoda, N. Muro, D. Shibata, M. Medebielle,
Heterocycles, 76, 215 (2008). - Synthesis of Novel Fluorinated 4H-Benzo[h]chromen-4-one and 4H-pyrano[3,2-h]quinolin-4-one Derivatives,
M. Medebielle, R. Keirouz, E. Okada, D. Shibata, W. R. Dolbier Jr.,
Tetrahedron Lett., 49, 589 (2008). - A Facile and Convenient Synthetic Method for 2-Bis(trifluoroacetyl)methylene- and
2-Trifluoroacetylmethylene-2,3-dihydro-3-methylthiazoles,
N. Ota, E. Okada, Y. Kamitori, D. Shibata, M. Medebielle,
Heterocycles, 74, 721 (2007). - Thermal Reaction of 5-Aryl-6-trifluoromethyl-3,6-dihydro-2H-[1,3,4]oxadiazines Accessing
5-Trifluoromethylimidazoles,
Y. Kamitori, T. Sekiyama, E. Okada,
Heterocycles, 74, 351 (2007). - Reaction of 3-Hydrazono-1,1,1-trifluoro-2-alkanones with Lawesson Reagent
Accessing 6-Trifluoromethyl-3,6-dihydro-2H-[1,3,4]thiadiazines,
Y. Kamitori, T. Sekiyama, E. Okada,
Heterocycles, 71, 2219 (2007). - Organic Molecules of Biological Interest: New Synthetic Approaches Using Tetrakis(dimethylamino)ethylene (TDAE),
M. Medebielle, B. Langlois, T. Billard, P. Vanelle, T. Terme, W. R. Dolbier, Jr., E. Okada, K.Kato,
Act. Chim. Ther., 33, A1-A18 (2007). - Indium-mediated Reduction of β-Aminovinyl Chloro-difluoromethylated Ketones in the presence of
Heteroaryl Aldehydes. A Mild Entry to Novel Difluoromethylene Enaminone Derivatives,
F. Fenain, M. Medebielle, M Rocher, O. Onomura, E. Okada, D. Shibata,
J. Fluorine Chem., 128, 1286 (2007). - Synthesis of Novel Fluorinated 4-Aminoquinoline Derivatives,
M. Medebielle, S. Hohn, E. Okada, H. Myoken, D. Shibata,
Tetrahedron Lett., 46, 7817 (2005). - Acid Catalyzed Cyclization Reaction of 3-Hydrazono-1,1,1-trifluoro-2-alkanones
to 6-Trifluoromethyl-3,6-dihydro-2H-[1,3,4]oxadiazines,
Y. Kamitori, T. Sekiyama,
Heterocycles, 65, 2139 (2005). - A Convenient Synthesis of Trifluoro- methylpyridazines from 3-Hydrazono-1,1,1-
trifluoroalkan-2-ones,
Y. Kamitori, T. Sekiyama,
Heterocycles, 63, 707 (2004). - 3-Dimethylhydrazono-1,1,1-trifluoro-2-propanone as a Useful Synthetic Equivalent
of Trifluoropyruvaldehyde Application to Synthesis of Fluorine-containing Heterocycles,
Y. Kamitori,
Heterocycles, 60, 1185 (2003). - Synthesis and Aromatic Nucleophilic N-N, N-S and N-O Exchange Reactions of
N,N-Dimethyl-2-trifluoroacetyl-1-naphthylamine,
E. Okada, Y. Otsuki, M. Shinohara, M. Medebielle, Y. Shimizu, H. Takeuchi,
Tetrahedron Lett., 44, 741 (2003). - Indium-Mediated Reformatsky-Type Reaction of β-Amnovinyl Chlorodifluoromethyl
Ketones with Heteroaryl Aldehydes,
M. Medebielle, O. Onomura, R. Keirouz, E. Okada, H. Yano, T. Terauchi,
Synthesis, 2601 (2002). - Tetrakis(dimethylamino)ethylene (TDAE) Mediated Addition of Heterocyclic
Difluoromethyl Anions to Heteroaryl Aldehydes. A Facile Synthetic Method
for New gem-Difluorinated Alcohols Derived from 4-Bromo-1-naphthylamine and
8-Quinolylamine,
M. Medebielle, R. Keirouz, E. Okada, T. Ashida,
Synlett, 821 (2001). - A Facile Synthesis of Fluorine-containing Heterocycles
Use of 1,1,1-Trifluoro-2-alkanones as a Convenient Synthetic Intermediate,
Y. Kamitori,
J. Heterocyclic Chem., 38, 773 (2001). - 3-(Dimethylhydrazono)-1,1,1,4,4,4-hexafluoro-2-butanone as Latent Perfluorobiacetyl,
Y. Kamitori,
Tetrahedron Lett., 41, 9267 (2000). - Facile Syntheses of Fluorine-Containing Pyrazolo[4,3-h]quinolines and
1H-1,4-Diazepino[6,5-h]-quinolines,
E. Okada, N. Tsukushi, N. Shimomura,
Synthesis, 1822 (2000). - A Simple and Efficient Synthetic Method for Fluorine-Containing 1,10-Phenanthrolines,
E. Okada, N. Tsukushi,
Synthesis, 499 (2000). - [4+2] Cycloaddition Reaction of 3-Hydrazono-1,1,1-trifluoro-2-alkanones to
4,5-Bis(trifluoromethyl)pyridazines,
Y. Kamitori,
Heterocycles, 53, 1065 (2000). - A Simple and Efficient Synthetic Method for Fluorine-Containing
7H-[1]Benzothiopyrano[3,2-h]-quinolines,
E. Okada, N. Tsukushi,
Heterocycles, 53, 709 (2000). - Aromatic Nucleophilic N-N, N-S and N-O Exchange Reactions: Efficient Synthesis of
5,7-Bis-(trifluoroacetyl)-8-quinolylamines, Sulfides and Ethers,
E. Okada, N. Tsukushi, N. Shimomura,
Synthesis, 237 (2000). - A Simple Synthetic Method for 3-Trifluoroacetylated 4-Aminoquinolines from
4-Dimethylaminoquinoline by Novel Trifluoroacetylation and N-N Exchange Reactions,
E. Okada, T. Sakaemura, N. Shimomura,
Chem. Lett., 50 (2000). - A Facile and Convenient Synthetic Method for Fluorine-Containing 1H-Pyrrolo[3,2-h]quinolines,
E. Okada, N. Tsukushi,
Heterocycles, 53, 127 (2000). - A Convenient Synthesis of 4-Trifluoromethylimidazole- 1-ols,
Y. Kamitori,
Heterocycles, 53, 107 (2000). - A Simple and Convenient Synthetic Method for Fluorine-Containing Benzo[b][1,10]phenanthrolines,
E. Okada, N. Tsukushi, T. Sakaemura,
Heterocycles, 51, 2697 (1999). - A Convenient Synthesis of 4-Trifluoromethyl-4H-[1,5,2]dioxazines and
4-Trifluoromethyl-6H-[1,2,5]oxadiazines,
Y. Kamitori,
J. Heterocyclic Chem., 36, 917 (1999). - A Facile and Convenient Synthetic Method for Fluorine-Containing
1,2-Dihydropyrido[3,2-h]quinazolines and Pyrido[3,2-h]quinazolines,
E. Okada, N. Tsukushi,
Heterocycles, 51, 2471 (1999). - A Convenient and Facile Synthesis of 3-Trifluoro- methyl-1,2,5-oxadiazoles with the Use of Silica
Gel as an Effective Catalyst,
Y. Kamitori,
Heterocycles, 51, 627 (1999). - Aromatic Nucleophilic N-N Exchange Reaction of N,N-Dimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine
with Various Amines: A Facile Synthetic Method for 5,7-Bis(trifluoroacetyl)-8-quinolyl-amines,
E. Okada, N. Tsukushi,
Synlett, 210 (1999). - Aromatic Nucleophilic N-N, N-S and N-O Exchange Reactions of N,N-Dimethyl-2-trifluoroacetyl-4-
halo-1-naphthylamines with Various Amines, Thiols and Alcohols: A Facile Synthesis of
2-Trifluoroacetyl-4-halo-1-naphthylamines, Sulfides and Ethers,
E. Okada, N. Tsukushi, Y. Otsuki, S. Nishiyama, T. Fukuda,
Synlett, 126 (1999). - A Simple Synthetic Method for Fluorine-Containing 4H-Pyrano[3,2-d]isoxazoles and
4-Cyanoethylisoxazoles from 5-Trifluoroacetyl-2-methoxy-3,4-dihydro-2H-pyran
with HydroxylamineHydrochloride,
E. Okada, H. Okumura, Y. Nishida and T. Kitahora,
Heterocycles, 50, 377 (1999). - A Convenient Synthesis of 4,5-Bis(trifluoromethyl)pyridazines,
Y. Kamitori, M. Hojo, T. Yoshioka,
Heterocycles, 48, 2221 (1998).
